The neutrino was not detected directly until 1956, when American physicists Frederick Reines and Clyde L. Cowan recognized them by their impact with subnuclear particles in mineral water. In 1962 it was found that the neutrino associated with the muon (the muon neutrino) is distinct from that associated with the electron (the electron neutrino). A third type, the tau neutrino, associated with the tau particle, was identiified in the mid-1970s but not detected until 2000. Each type of neutrino has its own antiparticle.

According to the so-called oscillation theory, neutrinos can change from one type to another as they travel through space; in order to make these transformations, neutrinos have to have a tiny amount of mass and not be massless, as was originally theorized. Beginning in the late 1960s a number of experiments designed to detect neutrinos failed to produce the expected results when fewer than expected neutrinos were detected, a result that could be explained by the conversion of the type (or flavor) of neutrino the experiments were trying to detect into another type, a process known as flavor oscillation. In 1995 and again in 1996 a team at the Los Alamos National Laboratory claimed to have detected the oscillation of muon antineutrinos into electron antineutrinos, and in 1998 the participants in the Super-Kamiokande experiment in Japan, which examined neutrinos produced by the interaction of cosmic rays with the upper atmosphere, announced that they had discovered evidence that neutrinos oscillate and must have mass. In 2001 researchers at the Sudbury Neutron Observatory in Ontario, Canada, found evidence that the electron neutrinos produced by fusion reactions within the sun can change into tau and muon neutrinos as they travel to the earth. Additional work by Fermilab in Illinois and Minnesota confirmed (2006) that neutrinos have mass. This is significant because of its implications for the composition and evolution of the universe, including the rate of the universe's expansion. Neutrinos would exert gravitational effects and thus could account for some of the dark matter in the universe.

See also neutrino astronomy.